Structure of Calcarisporiella thermophila Hsp104 disaggregase that antagonizes diverse proteotoxic misfolding events

Hsp104 is an AAA+ protein disaggregase with powerful amyloid-remodeling activity. All nonmetazoan eukaryotes express Hsp104 while eubacteria express an Hsp104 ortholog, ClpB. However, most studies have focused on Hsp104 from Saccharomyces cerevisiae and ClpB orthologs from two eubacterial species. T...

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Gepubliceerd in:Structure
Hoofdauteurs: Michalska, Karolina, Zhang, Kaiming, March, Zachary M., Hatzos-Skintges, Catherine, Pintilie, Grigore, Bigelow, Lance, Castellano, Laura M., Miles, Leann J., Jackrel, Meredith E., Chuang, Edward, Jedrzejczak, Robert, Shorter, James, Chiu, Wah, Joachimiak, Andrzej
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403000/
https://ncbi.nlm.nih.gov/pubmed/30595457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2018.11.001
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