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Immunoglobulin deposition on biomolecule corona determines complement opsonisation efficiency of preclinical and clinical nanoparticles

Deposition of complement factors (opsonisation) on nanoparticles may promote clearance from the blood by macrophages and trigger proinflammatory responses, but the mechanisms regulating the efficiency of complement activation are poorly understood. We previously demonstrated that opsonisation of sup...

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Detalles Bibliográficos
Publicado en:Nat Nanotechnol
Main Authors: Vu, Vivian P., Gifford, Geoffrey B., Chen, Fangfang, Benasutti, Halli, Wang, Guankui, Groman, Ernest V., Scheinman, Robert, Saba, Laura, Moghimi, Seyed Moein, Simberg, Dmitri
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402998/
https://ncbi.nlm.nih.gov/pubmed/30643271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41565-018-0344-3
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