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Homologous recombination and the formation of complex genomic rearrangements

The maintenance of genome integrity involves multiple independent DNA damage avoidance and repair mechanisms. Yet, the origin and pathways of the focal chromosomal reshuffling phenomena collectively referred to as chromothripsis remain mechanistically obscure. Here, we discuss the role, mechanisms,...

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Bibliografiske detaljer
Udgivet i:Trends Cell Biol
Main Authors: Piazza, Aurèle, Heyer, Wolf-Dietrich
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402879/
https://ncbi.nlm.nih.gov/pubmed/30497856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2018.10.006
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