Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming

Understanding the molecular programs that guide differentiation during development is a major challenge. Here, we introduce Waddington-OT, an approach for studying developmental time courses to infer ancestor-descendant fates and model the regulatory programs that underlie them. We apply the method...

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Veröffentlicht in:Cell
Hauptverfasser: Schiebinger, Geoffrey, Shu, Jian, Tabaka, Marcin, Cleary, Brian, Subramanian, Vidya, Solomon, Aryeh, Gould, Joshua, Liu, Siyan, Lin, Stacie, Berube, Peter, Lee, Lia, Chen, Jenny, Brumbaugh, Justin, Rigollet, Philippe, Hochedlinger, Konrad, Jaenisch, Rudolf, Regev, Aviv, Lander, Eric S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402800/
https://ncbi.nlm.nih.gov/pubmed/30712874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.01.006
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