Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming

Understanding the molecular programs that guide differentiation during development is a major challenge. Here, we introduce Waddington-OT, an approach for studying developmental time courses to infer ancestor-descendant fates and model the regulatory programs that underlie them. We apply the method...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Cell
Autors principals: Schiebinger, Geoffrey, Shu, Jian, Tabaka, Marcin, Cleary, Brian, Subramanian, Vidya, Solomon, Aryeh, Gould, Joshua, Liu, Siyan, Lin, Stacie, Berube, Peter, Lee, Lia, Chen, Jenny, Brumbaugh, Justin, Rigollet, Philippe, Hochedlinger, Konrad, Jaenisch, Rudolf, Regev, Aviv, Lander, Eric S.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402800/
https://ncbi.nlm.nih.gov/pubmed/30712874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.01.006
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars