Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity

N-methyl-D-aspartate (NMDA) receptor (NMDAR) is highly compartmentalized in neurons, and its dysfunction has been implicated in various neuropsychiatric and neurodegenerative disorders. Recent failure to exploit NMDAR antagonization as a potential therapeutic target has driven the need to identify m...

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Dettagli Bibliografici
Pubblicato in:iScience
Autori principali: Lin, Raozhou, Duan, Zhigang, Sun, Haitao, Fung, Man-Lung, Chen, Hansen, Wang, Jing, Lau, Chi-Fai, Yang, Di, Liu, Yu, Ni, Yanxiang, Wang, Zai, Cui, Ju, Wu, Wutian, Yung, Wing-Ho, Chan, Ying-Shing, Lo, Amy C.Y., Xia, Jun, Shen, Jiangang, Huang, Jian-Dong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402234/
https://ncbi.nlm.nih.gov/pubmed/30826728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.02.009
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