PGC-1α Negatively Regulates Extrasynaptic NMDAR Activity and Excitotoxicity

Underexpression of the transcriptional coactivator PGC-1α is causally linked to certain neurodegenerative disorders, including Huntington's Disease (HD). HD pathoprogression is also associated with aberrant NMDAR activity, in particular an imbalance between synaptic versus extrasynaptic (NMDAR(...

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Autors principals: Puddifoot, Clare, Martel, Marc-Andre, Soriano, Francesc X., Camacho, Alberto, Vidal-Puig, Antonio, Wyllie, David J. A., Hardingham, Giles E.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2012
Matèries:
Brief Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359835/
https://ncbi.nlm.nih.gov/pubmed/22593067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6407-11.2012
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