Kaposi’s Sarcoma-Associated Herpesvirus LANA-Adjacent Regions with Distinct Functions in Episome Segregation or Maintenance

Kaposi’s sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) is a 1,162-amino-acid protein that mediates episome persistence of viral genomes. LANA binds the KSHV terminal-repeat (TR) sequence through its carboxy-terminal domain to mediate DNA replication. LANA simultaneo...

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Bibliographic Details
Published in:J Virol
Main Authors: Juillard, Franceline, De León Vázquez, Erika, Tan, Min, Li, Shijun, Kaye, Kenneth M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401465/
https://ncbi.nlm.nih.gov/pubmed/30626680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02158-18
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