Establishment of a Novel Humanized Mouse Model To Investigate In Vivo Activation and Depletion of Patient-Derived HIV Latent Reservoirs

Curing HIV infection has been thwarted by the persistent reservoir of latently infected CD4(+) T cells, which reinitiate systemic infection after antiretroviral therapy (ART) interruption. To evaluate reservoir depletion strategies, we developed a novel preclinical in vivo model consisting of immuno...

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Vydáno v:J Virol
Hlavní autoři: Flerin, Nina C., Bardhi, Ariola, Zheng, Jian Hua, Korom, Maria, Folkvord, Joy, Kovacs, Colin, Benko, Erika, Truong, Ronald, Mota, Talia, Connick, Elizabeth, Jones, R. Brad, Lynch, Rebecca M., Goldstein, Harris
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401459/
https://ncbi.nlm.nih.gov/pubmed/30626677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02051-18
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