Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis

BACKGROUND: CEACAM1 regulates insulin sensitivity by promoting insulin clearance. Accordingly, global C57BL/6J.Cc1(−/−) null mice display hyperinsulinemia due to impaired insulin clearance at 2 months of age, followed by insulin resistance, steatohepatitis, visceral obesity and leptin resistance at...

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Vydáno v:Metabolism
Hlavní autoři: Ghadieh, Hilda E., Russo, Lucia, Muturi, Harrison T., Ghanem, Simona S., Manaserh, Iyad H., Noh, Hye Lim, Suk, Sujin, Kim, Jason K., Hill, Jennifer W., Najjar, Sonia M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401268/
https://ncbi.nlm.nih.gov/pubmed/30664851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2019.01.008
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