Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice

AIMS/HYPOTHESIS: The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1(−/−)) or with liver-specific inactivation (L-SACC1) of Cc1 (also known as Ceacam1) gene display hyperinsulinaemia resulting from impaired insulin c...

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Veröffentlicht in:Diabetologia
Hauptverfasser: Russo, Lucia, Muturi, Harrison T., Ghadieh, Hilda E., Ghanem, Simona S., Bowman, Thomas A., Noh, Hye Lim, Dagdeviren, Sezin, Dogbey, Godwin Y., Kim, Jason K., Heinrich, Garrett, Najjar, Sonia M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788286/
https://ncbi.nlm.nih.gov/pubmed/28913658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4432-y
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