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Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene
OBJECTIVE: Mice with global null mutation of Ceacam1 (Cc1(−/−)), display impairment of insulin clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manifest abnormal vascular permeability and elevated blo...
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| Publicado no: | Mol Metab |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5870095/ https://ncbi.nlm.nih.gov/pubmed/29396368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.01.009 |
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