Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene

OBJECTIVE: Mice with global null mutation of Ceacam1 (Cc1(−/−)), display impairment of insulin clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manifest abnormal vascular permeability and elevated blo...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Mol Metab
Main Authors: Russo, Lucia, Muturi, Harrison T., Ghadieh, Hilda E., Wisniewski, Alexander M., Morgan, Eric E., Quadri, Syed S., Landesberg, Gavin P., Siragy, Helmy M., Vazquez, Guillermo, Scalia, Rosario, Gupta, Rajesh, Najjar, Sonia M.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018
Assuntos:
Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870095/
https://ncbi.nlm.nih.gov/pubmed/29396368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.01.009
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares