Liver-specific rescuing of CEACAM1 reverses endothelial and cardiovascular abnormalities in male mice with null deletion of Ceacam1 gene

OBJECTIVE: Mice with global null mutation of Ceacam1 (Cc1(−/−)), display impairment of insulin clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manifest abnormal vascular permeability and elevated blo...

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Pubblicato in:Mol Metab
Autori principali: Russo, Lucia, Muturi, Harrison T., Ghadieh, Hilda E., Wisniewski, Alexander M., Morgan, Eric E., Quadri, Syed S., Landesberg, Gavin P., Siragy, Helmy M., Vazquez, Guillermo, Scalia, Rosario, Gupta, Rajesh, Najjar, Sonia M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870095/
https://ncbi.nlm.nih.gov/pubmed/29396368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.01.009
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