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KRAS-mutant colon cancer cells respond to combined treatment of ABT263 and axitinib

Significant challenges to develop selective and effective pharmacological inhibitors for important oncoproteins like RAS continue impeding the success to treat cancers driven by such mutations. In the present study, the ABT263 and axitinib combination imposed synergistic effects on RAS-mutant colon...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Wang, Guihua, Huang, Ying, Wu, Zhipeng, Zhao, Chunmei, Cong, Hui, Ju, Shaoqing, Wang, Xudong
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400663/
https://ncbi.nlm.nih.gov/pubmed/30674639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20181786
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