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KRAS-mutant colon cancer cells respond to combined treatment of ABT263 and axitinib

Significant challenges to develop selective and effective pharmacological inhibitors for important oncoproteins like RAS continue impeding the success to treat cancers driven by such mutations. In the present study, the ABT263 and axitinib combination imposed synergistic effects on RAS-mutant colon...

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Bibliografski detalji
Izdano u:Biosci Rep
Glavni autori: Wang, Guihua, Huang, Ying, Wu, Zhipeng, Zhao, Chunmei, Cong, Hui, Ju, Shaoqing, Wang, Xudong
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400663/
https://ncbi.nlm.nih.gov/pubmed/30674639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20181786
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