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KRAS-mutant colon cancer cells respond to combined treatment of ABT263 and axitinib

Significant challenges to develop selective and effective pharmacological inhibitors for important oncoproteins like RAS continue impeding the success to treat cancers driven by such mutations. In the present study, the ABT263 and axitinib combination imposed synergistic effects on RAS-mutant colon...

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Bibliografische gegevens
Gepubliceerd in:Biosci Rep
Hoofdauteurs: Wang, Guihua, Huang, Ying, Wu, Zhipeng, Zhao, Chunmei, Cong, Hui, Ju, Shaoqing, Wang, Xudong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Portland Press Ltd. 2019
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400663/
https://ncbi.nlm.nih.gov/pubmed/30674639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20181786
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