GLP-1 signaling suppresses menin’s transcriptional block by phosphorylation in β cells

Both menin and glucagon-like peptide 1 (GLP-1) pathways play central yet opposing role in regulating β cell function, with menin suppressing, and GLP-1 promoting, β cell function. However, little is known as to whether or how GLP-1 pathway represses menin function. Here, we show that GLP-1 signaling...

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Vydáno v:J Cell Biol
Hlavní autoři: Xing, Bowen, Ma, Jian, Jiang, Zongzhe, Feng, Zijie, Ling, Sunbin, Szigety, Katy, Su, Wen, Zhang, Longmei, Jia, Ruirui, Sun, Yanmei, Zhang, Lin, Kong, Xiangchen, Ma, Xiaosong, Hua, Xianxin
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400573/
https://ncbi.nlm.nih.gov/pubmed/30792230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201805049
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