Menin and Daxx interact to block neuroendocrine tumors through epigenetic control of the membrane metallo-endopeptidase MME

Neuroendocrine tumors (NET) often harbor loss-of-function mutations in the MEN1 and DAXX tumor suppressor genes. Here we report that the products of these genes, menin and Daxx, interact directly with each other to suppress the proliferation of NET cells, to a large degree by inhibiting expression o...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Feng, Zijie, Wang, Lei, Sun, Yanmei, Jiang, Zongzhe, Domsic, John, An, Chiying, Xing, Bowen, Tian, Jingjing, Liu, Xiuheng, Metz, David C., Yang, Xiaolu, Marmorstein, Ronen, Ma, Xiaosong, Hua, Xianxin
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243199/
https://ncbi.nlm.nih.gov/pubmed/27872097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1567
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