Menin and Daxx interact to block neuroendocrine tumors through epigenetic control of the membrane metallo-endopeptidase MME

Neuroendocrine tumors (NET) often harbor loss-of-function mutations in the MEN1 and DAXX tumor suppressor genes. Here we report that the products of these genes, menin and Daxx, interact directly with each other to suppress the proliferation of NET cells, to a large degree by inhibiting expression o...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Feng, Zijie, Wang, Lei, Sun, Yanmei, Jiang, Zongzhe, Domsic, John, An, Chiying, Xing, Bowen, Tian, Jingjing, Liu, Xiuheng, Metz, David C., Yang, Xiaolu, Marmorstein, Ronen, Ma, Xiaosong, Hua, Xianxin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243199/
https://ncbi.nlm.nih.gov/pubmed/27872097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1567
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