Menin and Daxx interact to block neuroendocrine tumors through epigenetic control of the membrane metallo-endopeptidase MME

Neuroendocrine tumors (NET) often harbor loss-of-function mutations in the MEN1 and DAXX tumor suppressor genes. Here we report that the products of these genes, menin and Daxx, interact directly with each other to suppress the proliferation of NET cells, to a large degree by inhibiting expression o...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Feng, Zijie, Wang, Lei, Sun, Yanmei, Jiang, Zongzhe, Domsic, John, An, Chiying, Xing, Bowen, Tian, Jingjing, Liu, Xiuheng, Metz, David C., Yang, Xiaolu, Marmorstein, Ronen, Ma, Xiaosong, Hua, Xianxin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5243199/
https://ncbi.nlm.nih.gov/pubmed/27872097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1567
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