The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia

Leukemia phenotypes vary with age of onset. Delineating mechanisms of age specificity in leukemia could improve disease models and uncover new therapeutic approaches. Here, we used heterochronic transplantation of leukemia driven by MLL/KMT2A translocations to investigate the contribution of the age...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Rowe, R. Grant, Lummertz da Rocha, Edroaldo, Sousa, Patricia, Missios, Pavlos, Morse, Michael, Marion, William, Yermalovich, Alena, Barragan, Jessica, Mathieu, Ronald, Jha, Deepak Kumar, Fleming, Mark D., North, Trista E., Daley, George Q.
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400531/
https://ncbi.nlm.nih.gov/pubmed/30728174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181765
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