The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia

Leukemia phenotypes vary with age of onset. Delineating mechanisms of age specificity in leukemia could improve disease models and uncover new therapeutic approaches. Here, we used heterochronic transplantation of leukemia driven by MLL/KMT2A translocations to investigate the contribution of the age...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Med
Auteurs principaux: Rowe, R. Grant, Lummertz da Rocha, Edroaldo, Sousa, Patricia, Missios, Pavlos, Morse, Michael, Marion, William, Yermalovich, Alena, Barragan, Jessica, Mathieu, Ronald, Jha, Deepak Kumar, Fleming, Mark D., North, Trista E., Daley, George Q.
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2019
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400531/
https://ncbi.nlm.nih.gov/pubmed/30728174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181765
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