IDH1-R132H acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage response

Glioma patients whose tumors carry a mutation in Isocitrate Dehydrogenase 1 (IDH1(R132H)) are younger at diagnosis and live longer. IDH1 mutations co-occur with other molecular lesions, such as 1p/19q co-deletion, inactivating mutations in the tumor suppressor protein 53 (TP53) gene, and loss of fun...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Transl Med
Egile Nagusiak: Núñez, Felipe J., Mendez, Flor M., Kadiyala, Padma, Alghamri, Mahmoud S., Savelieff, Masha G., Garcia-Fabiani, Maria B., Haase, Santiago, Koschmann, Carl, Calinescu, Anda-Alexandra, Kamran, Neha, Patel, Rohin, Carney, Stephen, Guo, Marissa Z., Edwards, Marta, Ljungman, Mats, Qin, Tingting, Sartor, Maureen A., Tagett, Rebecca, Venneti, Sriram, Brosnan-Cashman, Jacqueline, Meeker, Alan, Gorbunova, Vera, Zhao, Lili, Kremer, Daniel M., Zhang, Li, Lyssiotis, Costas A., Jones, Lindsey, Herting, Cameron J., Ross, James L., Hambardzumyan, Dolores, Hervey-Jumper, Shawn, Figueroa, Maria E., Lowenstein, Pedro R., Castro, Maria G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400220/
https://ncbi.nlm.nih.gov/pubmed/30760578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaq1427
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