PDTM-20. THE HISTONE MUTATION H3.3-G34R ENCOUNTERED IN PEDIATRIC HIGH GRADE GLIOMA MODIFIES THE TUMOR IMMUNE MICROENVIRONMENT RENDERING IT MORE PERMISSIVE FOR IMMUNE MEDIATED THERAPIES

Pediatric high grade gliomas (pHGGs) have a median survival (MS) of 9–15 months and are the most common malignant brain tumors in children. No significant improvement in the MS of these patients has been registered in decades. Thus, a representative in vivo model to study these tumors is critical. R...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: B Garcia-Fabiani, Maria, Kadiyala, Padma, Haase, Santiago, Alghamri, Mahmoud, Comba, Andrea, Nunez, Felipe, Whalen, Matthew, Lowenstein, Pedro, Castro, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Pediatric Tumors
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847884/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.796
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