GENE-35. IDH1-R132H INDUCES AN EPIGENETIC REPROGRAMMING IN GLIOMA IMPACTING MEDIAN SURVIVAL, DNA-DAMAGE RESPONSE AND RADIO-SENSITIVITY

IDH1-R132H is the most common mutation in lower-grade glioma and secondary glioblastoma. It is expressed in combination with ATRX and p53 inactivation in a mIDH1 glioma subtype which has been associated with better prognosis. We hypothesized that this is mediated by the impact of epigenetic changes...

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Udgivet i:Neuro Oncol
Main Authors: Nunez, Felipe, Mendez, Flor, Kadiyala, Padma, Alghamri, Mahmoud, Carney, Stephen, Ljungman, Mats, Qin, Tingting, Sartor, Maureen, Venneti, Sriram, Lyssiotis, Costas, Costello, Joseph, Herting, Cameron, Hambardzumyan, Dolores, Figueroa, Maria, Lowenstein, Pedro, Castro, Maria
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216856/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.461
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