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Complementary Steric Engineering at the Protein–Ligand Interface for Analogue-Sensitive TET Oxygenases
Ten-eleven translocation (TET) enzymes employ O(2), earth-abundant iron, and 2-ketoglutarate (2KG) to perform iterative C–H oxidation of 5-methylcytosine in DNA to control expression of the mammalian genome. Given that more than 60 such C–H oxygenases are present in humans, determining context-depen...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6400064/ https://ncbi.nlm.nih.gov/pubmed/30028600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b05283 |
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