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Engineering Bromodomains with a Photoactive Amino Acid by Engaging ‘Privileged’ tRNA Synthetases
Site-specific placement of unnatural amino acids, particularly those responsive to light, offers an elegant approach to control protein function and capture their fleeting ‘interactome’. Herein, we have resurrected 4-(trifluoromethyldiazirinyl)-phenylalanine, an underutilized photo-crosslinker, by i...
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| Publicat a: | Chem Commun (Camb) |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7146825/ https://ncbi.nlm.nih.gov/pubmed/32107512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9cc09891g |
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