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Structures of an RNA Polymerase Promoter Melting Intermediate Elucidate DNA Unwinding
A key regulated step of transcription in all cellular organisms is promoter melting by the RNA polymerase (RNAP) to form the open promoter complex(1–3). To generate the open complex, the conserved catalytic core of the RNAP combines with initiation factors to locate promoter DNA, unwind 12–14 base p...
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| Udgivet i: | Nature |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6399747/ https://ncbi.nlm.nih.gov/pubmed/30626968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0840-5 |
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