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Structures of an RNA Polymerase Promoter Melting Intermediate Elucidate DNA Unwinding

A key regulated step of transcription in all cellular organisms is promoter melting by the RNA polymerase (RNAP) to form the open promoter complex(1–3). To generate the open complex, the conserved catalytic core of the RNAP combines with initiation factors to locate promoter DNA, unwind 12–14 base p...

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Pubblicato in:Nature
Autori principali: Boyaci, Hande, Chen, James, Jansen, Rolf, Darst, Seth A., Campbell, Elizabeth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399747/
https://ncbi.nlm.nih.gov/pubmed/30626968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0840-5
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