Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes

Autophagy is the major mechanism involved in degradation and recycling of intracellular components, and its alterations have been proposed to cause beta cell dysfunction. In this study, we explored the effects of autophagy modulation in human islets under conditions associated to endoplasmic reticul...

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Veröffentlicht in:Front Endocrinol (Lausanne)
Hauptverfasser: Bugliani, M., Mossuto, S., Grano, F., Suleiman, M., Marselli, L., Boggi, U., De Simone, P., Eizirik, D. L., Cnop, M., Marchetti, P., De Tata, V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Endocrinology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399112/
https://ncbi.nlm.nih.gov/pubmed/30863363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2019.00052
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