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Generalizing a mathematical model of prion aggregation allows strain coexistence and co-stability by including a novel misfolded species

Prions are proteins capable of adopting misfolded conformations and transmitting these conformations to other normally folded proteins. Prions are most commonly known for causing fatal neurodegenerative diseases in mammals but are also associated with several harmless phenotypes in yeast. A distinct...

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Vydáno v:J Math Biol
Hlavní autoři: Lemarre, Paul, Pujo-Menjouet, Laurent, Sindi, Suzanne S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399074/
https://ncbi.nlm.nih.gov/pubmed/30116882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00285-018-1280-4
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