Strain-dependent profile of misfolded prion protein aggregates

Prions are composed of the misfolded prion protein (PrP(Sc)) organized in a variety of aggregates. An important question in the prion field has been to determine the identity of functional PrP(Sc) aggregates. In this study, we used equilibrium sedimentation in sucrose density gradients to separate P...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Morales, Rodrigo, Hu, Ping Ping, Duran-Aniotz, Claudia, Moda, Fabio, Diaz-Espinoza, Rodrigo, Chen, Baian, Bravo-Alegria, Javiera, Makarava, Natallia, Baskakov, Ilia V., Soto, Claudio
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753423/
https://ncbi.nlm.nih.gov/pubmed/26877167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20526
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