Strain-dependent profile of misfolded prion protein aggregates

Prions are composed of the misfolded prion protein (PrP(Sc)) organized in a variety of aggregates. An important question in the prion field has been to determine the identity of functional PrP(Sc) aggregates. In this study, we used equilibrium sedimentation in sucrose density gradients to separate P...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Morales, Rodrigo, Hu, Ping Ping, Duran-Aniotz, Claudia, Moda, Fabio, Diaz-Espinoza, Rodrigo, Chen, Baian, Bravo-Alegria, Javiera, Makarava, Natallia, Baskakov, Ilia V., Soto, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753423/
https://ncbi.nlm.nih.gov/pubmed/26877167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20526
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