Strain-dependent profile of misfolded prion protein aggregates

Prions are composed of the misfolded prion protein (PrP(Sc)) organized in a variety of aggregates. An important question in the prion field has been to determine the identity of functional PrP(Sc) aggregates. In this study, we used equilibrium sedimentation in sucrose density gradients to separate P...

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Publicado en:Sci Rep
Autores principales: Morales, Rodrigo, Hu, Ping Ping, Duran-Aniotz, Claudia, Moda, Fabio, Diaz-Espinoza, Rodrigo, Chen, Baian, Bravo-Alegria, Javiera, Makarava, Natallia, Baskakov, Ilia V., Soto, Claudio
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753423/
https://ncbi.nlm.nih.gov/pubmed/26877167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20526
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