Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors

Patients with liver cirrhosis may develop minimal hepatic encephalopathy (MHE) with mild cognitive impairment. Hyperammonemia is a main contributor to cognitive impairment in MHE, which is mediated by neuroinflammation. GABAergic neurotransmission is altered in hyperammonemic rats. We hypothesized t...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Malaguarnera, Michele, Llansola, Marta, Balzano, Tiziano, Gómez-Giménez, Belén, Antúnez-Muñoz, Carles, Martínez-Alarcón, Núria, Mahdinia, Rahebeh, Felipo, Vicente
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397886/
https://ncbi.nlm.nih.gov/pubmed/30858801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00132
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