Bicuculline Reduces Neuroinflammation in Hippocampus and Improves Spatial Learning and Anxiety in Hyperammonemic Rats. Role of Glutamate Receptors

Patients with liver cirrhosis may develop minimal hepatic encephalopathy (MHE) with mild cognitive impairment. Hyperammonemia is a main contributor to cognitive impairment in MHE, which is mediated by neuroinflammation. GABAergic neurotransmission is altered in hyperammonemic rats. We hypothesized t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Pharmacol
Prif Awduron: Malaguarnera, Michele, Llansola, Marta, Balzano, Tiziano, Gómez-Giménez, Belén, Antúnez-Muñoz, Carles, Martínez-Alarcón, Núria, Mahdinia, Rahebeh, Felipo, Vicente
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019
Pynciau:
Pharmacology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397886/
https://ncbi.nlm.nih.gov/pubmed/30858801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00132
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