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Zinc ameliorates intestinal barrier dysfunctions in shigellosis by reinstating claudin-2 and -4 on the membranes

Whether zinc (Zn(2+)) regulates barrier functions by modulating tight-junction (TJ) proteins when pathogens such as Shigella alter epithelial permeability is still unresolved. We investigated the potential benefits of Zn(2+) in restoring impaired barrier function in vivo in Shigella-infected mouse t...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Sarkar, Paramita, Saha, Tultul, Sheikh, Irshad Ali, Chakraborty, Subhra, Aoun, Joydeep, Chakrabarti, Manoj Kumar, Rajendran, Vazhaikkurichi M., Ameen, Nadia A., Dutta, Shanta, Hoque, Kazi Mirajul
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397338/
https://ncbi.nlm.nih.gov/pubmed/30406698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00092.2018
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