Effects of Small Molecule Calcium-Activated Chloride Channel Inhibitors on Structure and Function of Accessory Cholera Enterotoxin (Ace) of Vibrio cholerae

Cholera pathogenesis occurs due to synergistic pro-secretory effects of several toxins, such as cholera toxin (CTX) and Accessory cholera enterotoxin (Ace) secreted by Vibrio cholerae strains. Ace activates chloride channels stimulating chloride/bicarbonate transport that augments fluid secretion re...

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Udgivet i:PLoS One
Main Authors: Chatterjee, Tanaya, Sheikh, Irshad Ali, Chakravarty, Devlina, Chakrabarti, Pinak, Sarkar, Paramita, Saha, Tultul, Chakrabarti, Manoj K., Hoque, Kazi Mirajul
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634967/
https://ncbi.nlm.nih.gov/pubmed/26540279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141283
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