PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy

Personalized cancer therapy relies on identifying patient subsets that benefit from a therapeutic intervention and suggest alternative regimens for those who don’t. A new data integrative approach, based on graphical models, was applied on our multi-modal –omics, and clinical data cohort of metastat...

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Vydáno v:Sci Rep
Hlavní autoři: Abecassis, Irina, Sedgewick, Andrew J., Romkes, Marjorie, Buch, Shama, Nukui, Tomoko, Kapetanaki, Maria G., Vogt, Andreas, Kirkwood, John M., Benos, Panayiotis V., Tawbi, Hussein
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397203/
https://ncbi.nlm.nih.gov/pubmed/30824778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39542-2
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