Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways

Ribosome stalling triggers quality control pathways targeting the mRNA (NGD: no‐go decay) and the nascent polypeptide (RQC: ribosome‐associated quality control). RQC requires Hel2‐dependent uS10 ubiquitination and the RQT complex in yeast. Here, we report that Hel2‐dependent uS10 ubiquitination and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO J
Prif Awduron: Ikeuchi, Ken, Tesina, Petr, Matsuo, Yoshitaka, Sugiyama, Takato, Cheng, Jingdong, Saeki, Yasushi, Tanaka, Keiji, Becker, Thomas, Beckmann, Roland, Inada, Toshifumi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6396155/
https://ncbi.nlm.nih.gov/pubmed/30609991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100276
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