Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity

Neuronal excitotoxicity which is induced by exposure to excessive extracellular glutamate is shown to be involved in neuronal cell death in acute brain injury and a number of neurological diseases. High concentration of glutamate induces calcium deregulation which results in mitochondrial calcium ov...

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Publicado en:Mol Neurobiol
Autores principales: Angelova, Plamena R., Vinogradova, Darya, Neganova, Margarita E., Serkova, Tatiana P., Sokolov, Vladimir V., Bachurin, Sergey O., Shevtsova, Elena F., Abramov, Andrey Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6394642/
https://ncbi.nlm.nih.gov/pubmed/30008072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1204-8
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