Epigenetic events involved in organic cation transporter 1‐dependent impaired response of hepatocellular carcinoma to sorafenib

BACKGROUND AND PURPOSE: The expression of the human organic cation transporter‐1 (hOCT1, gene SLC22A1) is reduced in hepatocellular carcinoma (HCC). The molecular bases of this reduction and its relationship with the poor response of HCC to sorafenib were investigated. EXPERIMENTAL APPROACH: HCC tra...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Al‐Abdulla, Ruba, Lozano, Elisa, Macias, Rocio I R, Monte, Maria J, Briz, Oscar, O'Rourke, Colm J, Serrano, Maria A, Banales, Jesus M, Avila, Matias A, Martinez‐Chantar, Maria L, Geier, Andreas, Andersen, Jesper B, Marin, Jose J G
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393231/
https://ncbi.nlm.nih.gov/pubmed/30592786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14563
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