Epigenetic events involved in organic cation transporter 1‐dependent impaired response of hepatocellular carcinoma to sorafenib

BACKGROUND AND PURPOSE: The expression of the human organic cation transporter‐1 (hOCT1, gene SLC22A1) is reduced in hepatocellular carcinoma (HCC). The molecular bases of this reduction and its relationship with the poor response of HCC to sorafenib were investigated. EXPERIMENTAL APPROACH: HCC tra...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Al‐Abdulla, Ruba, Lozano, Elisa, Macias, Rocio I R, Monte, Maria J, Briz, Oscar, O'Rourke, Colm J, Serrano, Maria A, Banales, Jesus M, Avila, Matias A, Martinez‐Chantar, Maria L, Geier, Andreas, Andersen, Jesper B, Marin, Jose J G
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6393231/
https://ncbi.nlm.nih.gov/pubmed/30592786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14563
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