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The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy

A major difficulty in the treatment of cancers is the poor response of many tumors to pharmacological regimens. This situation can be accounted for by the existence of a variety of complex mechanisms of chemoresistance (MOCs), leading to reduced intracellular concentrations of active agents, changes...

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Detalhes bibliográficos
Main Authors: Marin, Jose JG, Monte, Maria J, Blazquez, Alba G, Macias, Rocio IR, Serrano, Maria A, Briz, Oscar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3880477/
https://ncbi.nlm.nih.gov/pubmed/24317012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.131
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