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Usefulness of the MRP2 promoter to overcome the chemoresistance of gastrointestinal and liver tumors by enhancing the expression of the drug transporter OATP1B1

Tumor response to chemotherapy is often limited by drug export through ABC proteins. To overcome this problem, here we have investigated the usefulness of inducing the expression of the multidrug uptake transporter OATP1B1 under the control of the MRP2 promoter (MRP2pr). Human hepatoma cells (Alexan...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Herraez, Elisa, Sanchez-Vicente, Laura, Macias, Rocio I.R., Briz, Oscar, Jose, J.G. Marin
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470996/
https://ncbi.nlm.nih.gov/pubmed/28423714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16119
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