Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage

Endoplasmic reticulum (ER) stress contributes to cardiovascular disease including heart failure. Interactions between the ER and mitochondria during ER stress can impair the mitochondrial respiratory chain and increase cell injury. p53 is a tumor suppressor protein that regulates apoptosis. p53 cont...

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Udgivet i:Front Cardiovasc Med
Main Authors: Chen, Qun, Thompson, Jeremy, Hu, Ying, Das, Anindita, Lesnefsky, Edward J.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Cardiovascular Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389610/
https://ncbi.nlm.nih.gov/pubmed/30838215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcvm.2019.00010
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