Inhibitors of HIF-1α and CXCR4 Mitigate the Development of Radiation Necrosis in Mouse Brain

PURPOSE: There is mounting evidence that, in addition to angiogenesis, hypoxia-induced inflammation via the hypoxia-inducible factor 1α (HIF-1α)–CXC chemokine receptor 4 (CXCR4) pathway may contribute to the pathogenesis of late-onset, irradiation-induced necrosis. This study investigates the mitiga...

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Detalhes bibliográficos
Publicado no:Int J Radiat Oncol Biol Phys
Main Authors: Yang, Ruimeng, Duan, Chong, Yuan, Liya, Engelbach, John A., Tsien, Christina I., Beeman, Scott C., Perez-Torres, Carlos J., Ge, Xia, Rich, Keith M., Ackerman, Joseph J.H., Garbow, Joel R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6389273/
https://ncbi.nlm.nih.gov/pubmed/29485043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2017.12.257
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