Continuous One Year Oral Administration of the Radiation Mitigator, MMS350, after Total-Body Irradiation, Restores Bone Marrow Stromal Cell Proliferative Capacity and Reduces Senescence in Fanconi Anemia (Fanca(−/−)) Mice

We quantitated age-related accumulation of senescent cells in irradiated Fanconi anemia (FA) (Fanca(−/−)) mouse cell lines in vitro and monitored the effect of continuous administration (via drinking water) of the water-soluble radiation mitigator, MMS350, on tissues in vivo over one year after 7.5...

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Publicado en:Radiat Res
Main Authors: Sivananthan, Aranee, Shields, Donna, Fisher, Renee, Hou, Wen, Zhang, Xichen, Franicola, Darcy, Epperly, Michael W., Wipf, Peter, Greenberger, Joel S.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6388094/
https://ncbi.nlm.nih.gov/pubmed/30499383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR15199.1
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