Breaking tolerance with engineered class I antigen-presenting molecules

Successful efforts to activate T cells capable of recognizing weak cancer-associated self-antigens have employed altered peptide antigens to activate T cell responses capable of cross-reacting on native tumor-associated self. A limitation of this approach is the requirement for detailed knowledge ab...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Parks, Christopher A., Henning, Kalli R., Pavelko, Kevin D., Hansen, Michael J., Van Keulen, Virginia P., Reed, Brendan K., Stone, Jennifer D., Schrum, Adam G., Gil, Diana, Kranz, David M., Bordner, Andrew J., Barry, Michael A., Pease, Larry R.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2019
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386718/
https://ncbi.nlm.nih.gov/pubmed/30728302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807465116
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