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Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood

Multiple sclerosis (MS) is an autoimmune disease targeting the central nervous system (CNS) mainly in young adults, and a breakage of immune tolerance to CNS self-antigens has been suggested to initiate CNS autoimmunity. Age and microbial infection are well-known factors involved in the development...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Yadav, Sudhir K., Boppana, Sridhar, Ito, Naoko, Mindur, John E., Mathay, Martin T., Patel, Ankoor, Dhib-Jalbut, Suhayl, Ito, Kouichi
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676872/
https://ncbi.nlm.nih.gov/pubmed/29078267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615715114
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