Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood

Multiple sclerosis (MS) is an autoimmune disease targeting the central nervous system (CNS) mainly in young adults, and a breakage of immune tolerance to CNS self-antigens has been suggested to initiate CNS autoimmunity. Age and microbial infection are well-known factors involved in the development...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Yadav, Sudhir K., Boppana, Sridhar, Ito, Naoko, Mindur, John E., Mathay, Martin T., Patel, Ankoor, Dhib-Jalbut, Suhayl, Ito, Kouichi
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5676872/
https://ncbi.nlm.nih.gov/pubmed/29078267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615715114
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