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Dimethyl Fumarate Suppresses Demyelination and Axonal Loss through Reduction in Pro-Inflammatory Macrophage-Induced Reactive Astrocytes and Complement C3 Deposition

Dimethyl fumarate (DMF) is an oral agent for relapsing-remitting multiple sclerosis (RRMS). In this study, we investigated the therapeutic mechanism of DMF using experimental autoimmune encephalomyelitis (EAE). DMF treatment decreased the proliferation of T cells and the production of IL-17A and GM-...

詳細記述

保存先:
書誌詳細
出版年:J Clin Med
主要な著者: Yadav, Sudhir K., Ito, Naoko, Soin, Devika, Ito, Kouichi, Dhib-Jalbut, Suhayl
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7922578/
https://ncbi.nlm.nih.gov/pubmed/33669652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm10040857
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