Dimethyl Fumarate Suppresses Demyelination and Axonal Loss through Reduction in Pro-Inflammatory Macrophage-Induced Reactive Astrocytes and Complement C3 Deposition

Dimethyl fumarate (DMF) is an oral agent for relapsing-remitting multiple sclerosis (RRMS). In this study, we investigated the therapeutic mechanism of DMF using experimental autoimmune encephalomyelitis (EAE). DMF treatment decreased the proliferation of T cells and the production of IL-17A and GM-...

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Bibliographic Details
Published in:J Clin Med
Main Authors: Yadav, Sudhir K., Ito, Naoko, Soin, Devika, Ito, Kouichi, Dhib-Jalbut, Suhayl
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7922578/
https://ncbi.nlm.nih.gov/pubmed/33669652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/jcm10040857
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